Life Style

Experiment offers new hope for fertility preservation in young boys

ANI | May 24, 2019 03:41 PM
Representative image

Washington D.C [U.S.A], May 24 (ANI): An experimental process of freezing testicular tissue gives hope to young boys to preserve their fertility before beginning medical treatments known to cause infertility, research claimed.

The study was published in the journal 'Human Reproduction'.

An estimated 2,000 U.S. boys and young men each year receive treatments or have cancers or blood disorders that place them at risk for infertility. While older youths who have undergone puberty can bank their sperm prior to undergoing sterilising doses of chemotherapy or radiation, there have been scant fertility preservation options for younger boys.

However, some older adolescents and young men are too sick or stressed to bank sperm. For patients with no sperm to a bank or who are too sick or stressed to bank sperm, the experimental procedure of freezing testicular tissue in anticipation that future cell- or tissue-based therapies can generate sperm is the only option.

Recent research in experimental models indicates that such testicular tissue biopsies contain stem cells, blank slate cells, hinting at the potential of generating sperm from biopsied tissue.

"This study demonstrates that undifferentiated stem and progenitor spermatogonia may be recovered from the testicular tissues of patients who are in the early stages of their treatment and have not yet received an ablative dose of therapy. The function of these spermatogonia was not tested," wrote lead author Hanna Valli-Pulaski, research assistant professor at the University of Pittsburgh.

Right now, haematologists and oncologists discuss future treatment options with patients and families, as well as possible long-term side effects, including infertility.

"This study is unique in that there is definitely a potential direct patient benefit. One of the reasons the study is compelling is that it presents a message of hope to the families. It's a message of survivorship: We are optimistic we can help your child get through this and think about long-term issues, like having their own families," said Michael Hsieh, director of transitional urology at Children's National.

In this phase of the study, testicular tissue was collected from centres in the U.S. and Israel from January 2011 to November 2018 and cryopreserved.

Patients designated 25 per cent of the tissue sample to be used for the research study; 75 per cent remains stored in liquid nitrogen at temperatures close to absolute zero for the patient's future use. The fertility preservation patients ranged from 5 months old to 34 years old, with an average age of 7.9 years.

Thirty-nine per cent of patients had started medical treatment prior to requesting fertility preservation. 16 per cent received non-alkylating chemotherapy while 23 per cent received alkylating chemotherapy, which directly damages the DNA of cancer cells.

The research team found that the number of undifferentiated spermatogonia per seminiferous tubule increases steadily with age until about age 11, then rise sharply.

"We recommend that all patients be counselled and referred for fertility preservation before beginning medical treatments known to cause infertility," said Dr Hsieh. (ANI)

Have something to say? Post your comment
Must Read
Health insurance Cards has made at Chinna village
Health insurance Cards has made at Chinna village
CTU’s School of Engineering & Technology wins Inter School Kabaddi Tournament
CTU’s School of Engineering & Technology wins Inter School Kabaddi Tournament
Everyone should contribute to enrich discussions in Parliament: PM Modi
Everyone should contribute to enrich discussions in Parliament: PM Modi
One day workshop on Digital Marketing Organized at Innocent Hearts Group of Institutions
One day workshop on Digital Marketing Organized at Innocent Hearts Group of Institutions
Health department to observe NSV fortnight from Nov 21 to Dec 4- DC
Health department to observe NSV fortnight from Nov 21 to Dec 4- DC
KMS 2019-20 paddy procurement crosses last year’s procurement status
KMS 2019-20 paddy procurement crosses last year’s procurement status
CT University holds Training and Placement session
CT University holds Training and Placement session
About 40,000 Spices of Migratory  Arrived at Harike Bird Sanctuary
About 40,000 Spices of Migratory Arrived at Harike Bird Sanctuary
Punjab Governor greets people on Parkash Utsav of Sri Guru Nanak Dev Ji
Punjab Governor greets people on Parkash Utsav of Sri Guru Nanak Dev Ji
Awareness meeting Organized By D.C Tarn Taran on Stubble Burn
Awareness meeting Organized By D.C Tarn Taran on Stubble Burn
District Level Programs begins to celebrate Guru Nanak Dev Ji Parkash Purb
District Level Programs begins to celebrate Guru Nanak Dev Ji Parkash Purb
4 major issues drowned Education sector of Punjab: Dr. Anshu Kataria
4 major issues drowned Education sector of Punjab: Dr. Anshu Kataria