Health

Study reveals how trans fats assist cell death

ANI | March 26, 2020 12:35 PM
Representative image

Washington D.C. [USA], Mar 26 (ANI): Researchers have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases. Their findings implicate their role in enhancing a mitochondrial signalling pathway that leads to programmed cell death.

These findings were published in the journal Scientific Reports.

"Accumulating evidence has associated the consumption of trans-fatty acids with various diseases, including some lifestyle diseases, atherosclerosis and dementia. But the underlying causes have remained largely unknown," says Atsushi Matsuzawa of Tohoku University's Laboratory of Health Chemistry.

Matsuzawa and a team of researchers explored the effects of two trans fats produced during industrial food manufacturing, elaidic and linoelaidic acids, on programmed cell death.

Cells instigate programmed cell death, which is called apoptosis if their DNA is damaged beyond repair. DNA damage can occur in response to a variety of factors, including reactive oxygen species, ultraviolet irradiation and anti-cancer drugs. Normally, cells counteract this process by repairing the lesions. But problems in the DNA damage response can lead to diseases also associated with trans fats.

The researchers induced DNA damage in cells using the anti-cancer drug doxorubicin. They found that elaidic and linoelaidic acids enhanced the apoptosis that followed. Other unsaturated fatty acids did not have the same effect.

Specifically, they found the fatty acids affected mitochondria, the energy-generating powerhouses of cells. DNA damage activates a signalling loop inside mitochondria that generates reactive oxygen species, which ultimately promote apoptosis. The industrial trans fats enhanced mitochondria's production of reactive oxygen species through this signalling loop, and thus increased apoptosis.

Apoptosis is thought to lead to the development and progression of disorders associated with industrial trans fats, such as the build-up of plaque inside arteries, called atherosclerosis.

"Our research revealed a novel toxic function and mechanism of action of trans-fatty acids, which can account for pathological mechanisms, including atherosclerosis," says Matsuzawa. "This significant finding will provide a molecular basis to understand how trans-fatty acids cause disease."

The researchers theorize that targeting this molecular mechanism with drugs might have a therapeutic effect on a diverse range of trans-fat-associated diseases. The team plans to further investigate this link and the extent to which this mechanism contributes to these diseases. They also aim to determine the differences in toxicity between different trans fats. (ANI)

Have something to say? Post your comment
Must Read
Punjab villages show the way to combatting COVID-19 with self isolation
Punjab villages show the way to combatting COVID-19 with self isolation
Novel Coronavirus (COVID-19):  Ex-commandant donates Rs 5 lakh out of his pension account for Punjab Chief Minister relief fund
Novel Coronavirus (COVID-19): Ex-commandant donates Rs 5 lakh out of his pension account for Punjab Chief Minister relief fund
DC and CP for transforming ‘self home quarantine’, ‘social distancing’ and ‘Theekari Pehras’ into a mass movement
DC and CP for transforming ‘self home quarantine’, ‘social distancing’ and ‘Theekari Pehras’ into a mass movement
Punjab sets up transport control rooms to ensure smooth movement of essentials
Punjab sets up transport control rooms to ensure smooth movement of essentials
One more Corona Positive patient dies in Punjab
One more Corona Positive patient dies in Punjab
Administration pulls up socks for smooth and hassle free procurement of wheat from April 15
Administration pulls up socks for smooth and hassle free procurement of wheat from April 15
Lockdown : Radha Soami Satsang Beas prepares 'langar' for needy in Punjab, other states
Lockdown : Radha Soami Satsang Beas prepares 'langar' for needy in Punjab, other states
Technical Education Board to give Rs 5 crore in CM's relief fund: Channi
Technical Education Board to give Rs 5 crore in CM's relief fund: Channi
MP, MLAs, DC, CP and SSP join heads for further expediting distribution of relief material to the needy and underprivileged sections of society
MP, MLAs, DC, CP and SSP join heads for further expediting distribution of relief material to the needy and underprivileged sections of society
The Department of Consumer Affairs will issue daily list of essential commodities during lockdown
The Department of Consumer Affairs will issue daily list of essential commodities during lockdown
DC and SSP leads flag march in Nakodar Sub-Division
DC and SSP leads flag march in Nakodar Sub-Division
Capt Amarinder directs DGP to finalise security plan for smooth procurement
Capt Amarinder directs DGP to finalise security plan for smooth procurement