Gadgets

Study reveals brain network mechanism causing spatial memory impairment

ANI | July 22, 2020 10:30 AM
Representative Image

Irvine (California) [USA], July 22 (ANI): A team of researchers has brought clarity on the brain network mechanism that causes spatial memory impairment.

Patients with Alzheimer's disease frequently suffer from spatial memory loss, such as no recognition of where they are, and forgetting where they put their belongings. They often show a wandering symptom, which is also a feature of spatial memory impairment.

Published in Neuron, the study titled, "Disrupted place cell remapping and impaired grid cells in a knockin model of Alzheimer's disease," reveals how the normal brain network function of hippocampus cells which works to discriminate a distinct spatial environment in a process called "remapping," was disrupted in Alzheimer's disease.

The study, done Alzheimer's disease model mice, found that this disruption of the hippocampus is most likely caused by the activity impairment of the entorhinal cortex, a brain region that supplies information to the hippocampus.

"We recorded the brain cell activity in the hippocampus, which is the memory center of the brain, responsible for spatial memory, among other things," said Kei Igarashi, PhD, an assistant professor in the Department of Anatomy & Neurobiology at the University of California, Irvine School of Medicine.

"Our findings could lead to the development of a method to reactivate brain activity of the entorhinal cortex, which may help establish new treatments for preventing the progression of spatial memory impairment in Alzheimer's disease patients," Igarashi added.

Igarashi has been studying brain network mechanisms for Alzheimer's disease since he started his lab in 2016. "Our memory comes from the activities of the brain network. To find out the cure for memory impairment in Alzheimer's disease, we need to understand how the network function is impaired," he said.

Igarashi is 2019 New Vision Research and BrightFocus Foundation award recipient. The first author of this study, Heechul Jun, is a MD/PhD student in the UCI Medical Scientist Training Program.

According to the Alzheimer's Association, there are an estimated 5.8 million Americans living with Alzheimer's disease. By 2050, that number is expected to increase to 13.8 million people.

Spatial memory impairment, such as wandering behavior, is one of the most troublesome symptoms in Alzheimer's disease, and it occurs in more than 60 percent of Alzheimer's patients. Despite recent molecular and cellular findings in Alzheimer's research, it is still largely unclear how deterioration of brain circuit function causes spatial memory loss. (ANI)

Have something to say? Post your comment
Must Read
Why would our MPs need direction from Capt Amarinder on farm bills, they knew their party stand, say Punjab Cong leaders & Ministers
Why would our MPs need direction from Capt Amarinder on farm bills, they knew their party stand, say Punjab Cong leaders & Ministers
NRI Woman, her father and relative booked on the complaint of husband
NRI Woman, her father and relative booked on the complaint of husband
Punjab Police busts another pro-Khalistan terror module with arrest of two
Punjab Police busts another pro-Khalistan terror module with arrest of two
Punjab CS assures private hospitals of full state govt support to address concerns in Covid fight
Punjab CS assures private hospitals of full state govt support to address concerns in Covid fight
Actress Mandy Takhar files complaint against fake video
Actress Mandy Takhar files complaint against fake video
Industry Dept extends timeline migration from FIIP to IBDP till Dec 31
Industry Dept extends timeline migration from FIIP to IBDP till Dec 31
Under Vijay Inder Singla's smart school policy about 6,000 schools have been converted into Smart Schools
Under Vijay Inder Singla's smart school policy about 6,000 schools have been converted into Smart Schools
Water cannon salute given to Rafale aircraft after air display at IAF airbase in Ambala
Water cannon salute given to Rafale aircraft after air display at IAF airbase in Ambala
Punjab CM announces relaxation in timings for non-essential shops, hotels & restaurants in urban areas till 9 pm
Punjab CM announces relaxation in timings for non-essential shops, hotels & restaurants in urban areas till 9 pm
Punjab gross GST collection stands at Rs.987.20 crore during August 2020
Punjab gross GST collection stands at Rs.987.20 crore during August 2020
India bans 118 more mobile apps including PUBG, WeChat
India bans 118 more mobile apps including PUBG, WeChat
Former President Pranab Mukherjee passes away
Former President Pranab Mukherjee passes away