Health

Researchers find better diet, glucose uptake in the brain lead to longer life in fruit flies

ANI | January 16, 2021 12:01 PM
Representative image (Image courtesy: Tokyo Metropolitan University)

Tokyo [Japan], January 16 (ANI): Researchers from Tokyo Metropolitan University have discovered that fruit flies with genetic modifications to enhance glucose uptake have significantly longer lifespans.

Looking at the brain cells of ageing flies, they found that better glucose uptake compensates for age-related deterioration in motor functions, and led to a longer life. The effect was more pronounced when coupled with dietary restrictions. This suggests healthier eating plus improved glucose uptake in the brain might lead to enhanced lifespans.

The brain is a particularly power-hungry part of our bodies, consuming 20% of the oxygen we take in and 25% of the glucose. That's why it's so important that it can stay powered, using the glucose to produce adenosine triphosphate (ATP), the "energy courier" of the body.

This chemical process, known as glycolysis, happens in both the intracellular fluid and a part of cells known as the mitochondria. But as we get older, our brain cells become less adept at making ATP, something that broadly correlates with less glucose availability.

That might suggest that more food for more glucose might actually be a good thing. On the other hand, it is known that a healthier diet actually leads to a longer life. Unravelling the mystery surrounding these two contradictory pieces of knowledge might lead to a better understanding of healthier, longer lifespans.

A team led by Associate Professor Kanae Ando studied this problem using Drosophila fruit flies. Firstly, they confirmed that brain cells in older flies tended to have lower levels of ATP, and lower uptake of glucose. They specifically tied this down to lower amounts of the enzymes needed for glycolysis.

To counteract this effect, they genetically modified flies to produce more of a glucose-transporting protein called hGut3. Amazingly, this increase in glucose uptake was all that was required to significantly improve the amount of ATP in cells.

More specifically, they found that more hGut3 led to less decrease in the production of the enzymes, counteracting the decline with age. Though this did not lead to an improvement in age-related damage to mitochondria, they also suffered less deterioration in locomotor functions.

But that's not all. In a further twist, the team put the flies with enhanced glucose uptake under dietary restrictions, to see how the effects interact. Now, the flies had even longer lifespans.

Curiously, the increased glucose uptake did not actually improve the levels of glucose in brain cells. The results point to the importance of not just how much glucose there is, but how efficiently it is used once taken into cells to make the energy the brain needs.

Though the anti-ageing benefits of a restricted diet have been shown in many species, the team were able to combine this with improved glucose uptake to leverage the benefits of both for even longer lifespans in a model organism. Further study may provide vital clues to how we might keep our brains healthier for longer. (ANI)

Have something to say? Post your comment
Must Read
Hoshiarpur Police to get tough against violations of COVID Norms
Hoshiarpur Police to get tough against violations of COVID Norms
On PM-Kisan's 2nd anniversary, PM Modi says govt doing everything possible to double farmers' income
On PM-Kisan's 2nd anniversary, PM Modi says govt doing everything possible to double farmers' income
Punjab CM virtually launches Rs 1087 crores development projects under Smart City and AMRUT schemes
Punjab CM virtually launches Rs 1087 crores development projects under Smart City and AMRUT schemes
Punjab Cabinet paves way for deemed approval of regulatory clearances & auto renewal for industrial projects
Punjab Cabinet paves way for deemed approval of regulatory clearances & auto renewal for industrial projects
Punjab Cabinet approves implementation of Mission Lal Lakir in all villages
Punjab Cabinet approves implementation of Mission Lal Lakir in all villages
Punjab Cabinet okays amendment to Indian Partnership Act, 1932 to revise nearly 90-year-old fee structure
Punjab Cabinet okays amendment to Indian Partnership Act, 1932 to revise nearly 90-year-old fee structure
Punjab Cabinet approves restructuring of 5 more departments to create 1875 new posts & boost efficiencies
Punjab Cabinet approves restructuring of 5 more departments to create 1875 new posts & boost efficiencies
Indian  Youth Congress president of Faridkot district allegedly shot dead in the evening.6 bullets fired at him at point-blank range near his car
Indian Youth Congress president of Faridkot district allegedly shot dead in the evening.6 bullets fired at him at point-blank range near his car
Jang-e-Azaadi memorial reopened for public after 11 months
Jang-e-Azaadi memorial reopened for public after 11 months
Three lakh school students participate in competitions dedicated to 400th Parkash Purb of Guru Tegh Bahadur ji: Vijay Inder Singla
Three lakh school students participate in competitions dedicated to 400th Parkash Purb of Guru Tegh Bahadur ji: Vijay Inder Singla
Punjab gears up for General Elections of Municipal Bodies
Punjab gears up for General Elections of Municipal Bodies
Earthquake measuring 6.1 jolts Jalandhar, strong tremors felt in J&K, Delhi-NCR
Earthquake measuring 6.1 jolts Jalandhar, strong tremors felt in J&K, Delhi-NCR