Health

Metabolic changes in patients with lupus linked to vitamin D deficiency

ANI | March 28, 2021 09:23 AM
Representative Image

London [UK], March 28 (ANI): The findings of a new study reveal that patients with lupus are more likely to have metabolic syndrome and insulin resistance, which are both the factors linked to heart disease if they have lower vitamin D levels.

An international research team, led by experts at the University of Birmingham and the University of Manchester, studied vitamin D levels in 1,163 SLE patients across 33 centres in 11 countries (UK, USA, Canada, Spain, The Netherlands, Sweden, Iceland, Switzerland, Turkey, South Korea and Mexico), publishing its findings in Rheumatology.

Researchers believe that boosting vitamin D levels may improve control of these cardiovascular risk factors, as well as improving long-term outcomes for patients with systemic lupus erythematosus (SLE).

Given that photosensitivity is a key feature of SLE, scientists say that a combination of avoiding the sun, using high-factor sunblock, and living in more northerly countries may contribute to lower levels of vitamin D in lupus patients. Patients with more severe diseases also had lower vitamin D levels.

Report co-author Dr John A Reynolds, Clinical Senior Lecturer in Rheumatology at the University of Birmingham, commented: "Our results suggest that co-existing physiological abnormalities may contribute to long-term cardiovascular risk early on in SLE.

"We found a link between lower levels of vitamin D and metabolic syndrome and insulin resistance. Further studies could confirm whether restoring vitamin D levels helps to reduce these cardiovascular risk factors and improve quality of life for patients with lupus."

Lupus is an uncommon incurable immune system illness, more common in women, where the immune system is overactive, causing inflammation anywhere in the body. Untreated, the condition threatens irreversible damage to major organs including kidneys, heart, lungs and brain.

Metabolic syndrome is a combination of diabetes, high blood pressure (hypertension), abnormal cholesterol levels, and obesity. People with metabolic syndrome are at greater risk of getting coronary heart disease, stroke and other conditions affecting the blood vessels.

The researchers note that patients with SLE have an excess cardiovascular risk, up to 50 times that seen in people without the condition - this cannot be attributed to traditional cardiovascular risk factors, such as high blood pressure or smoking, alone.

The mechanisms underlying the association between high blood pressure and low vitamin D in SLE are not clear, but researchers believe they may be linked to the impact of vitamin D deficiency on the renin-angiotensin hormone system, which regulates blood pressure, fluid, and electrolyte balance, as well as systemic vascular resistance.

"This is the largest-ever study examining associations between vitamin D levels and metabolic syndrome in SLE; it also has the advantage of being an international cohort with diverse racial and ethnic backgrounds - generating results that will be applicable across many settings," commented Dr. Reynolds. (ANI)

Have something to say? Post your comment
Must Read
Randhawa terms Rs.1400 per quintal hike in DAP as anti-farmer step
Randhawa terms Rs.1400 per quintal hike in DAP as anti-farmer step
More than 1100 doses administered to industrial workforce at mobile vaccination camps: Deputy Commissioner
More than 1100 doses administered to industrial workforce at mobile vaccination camps: Deputy Commissioner
Punjab CM virtually kicks off 100% free travel facility for women in govt buses within state
Punjab CM virtually kicks off 100% free travel facility for women in govt buses within state
Punjab Cabinet okays time-to-time remission benefits for convicts instead of just once
Punjab Cabinet okays time-to-time remission benefits for convicts instead of just once
e-IPHMDP embolden partnership and mutual cooperation among ITEC nations: Vini Mahajan
e-IPHMDP embolden partnership and mutual cooperation among ITEC nations: Vini Mahajan
Bharat Bandh: Complete bandh in Kapurthala
Bharat Bandh: Complete bandh in Kapurthala
Punjab CM digitally orders mass transfers of 19905 school teachers under Teachers Transfer Policy-2019
Punjab CM digitally orders mass transfers of 19905 school teachers under Teachers Transfer Policy-2019
Immediately stop police deployment from BJP ruled states to WB: TMC to Chief Electoral Officer
Immediately stop police deployment from BJP ruled states to WB: TMC to Chief Electoral Officer
Punjab: 24 DSP officers Transferred
Punjab: 24 DSP officers Transferred
More economic worries mean less caution about COVID-19: Study
More economic worries mean less caution about COVID-19: Study
Renowned academician and researcher Dr. Buta Singh Sidhu joins as vice chancellor of Maharaja Ranjit Singh Punjab Technical University, Bathinda
Renowned academician and researcher Dr. Buta Singh Sidhu joins as vice chancellor of Maharaja Ranjit Singh Punjab Technical University, Bathinda
Cut chores, kill chill time: New advice to boost children's academic outcomes
Cut chores, kill chill time: New advice to boost children's academic outcomes