Gadgets

Obesity raises risk of gum disease by inflating growth of bone-destroying cells: Study

ANI | November 15, 2021 04:07 PM
Representative image

Washington [US], November 15 (ANI): Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research.

The research sought to improve understanding of the connection between obesity and gum disease. The findings of the study were published in the 'Journal of Dental Research'.

The study, completed in an animal model, found that excessive inflammation resulting from obesity raises the number of myeloid-derived suppressor cells (MDSC), a group of immune cells that increase during illness to regulate immune function.

MDSCs, which originate in the bone marrow, develop into a range of different cell types, including osteoclasts (a cell that breaks down bone tissue).

Bone loss is a major symptom of gum disease and may ultimately lead to tooth loss. Also known as periodontal disease, gum disease affects more than 47 per cent of adults 30 years and older, according to the Centers for Disease Control and Prevention.

"Although there is a clear relationship between the degree of obesity and periodontal disease, the mechanisms that underpin the links between these conditions were not completely understood," said Keith Kirkwood, DDS, PhD, professor of oral biology in the UB School of Dental Medicine.

"This research promotes the concept that MDSC expansion during obesity to become osteoclasts during periodontitis is tied to increased alveolar bone destruction. Taken together, this data supports the view that obesity raises the risk of periodontal bone loss," said Kyuhwan Kwack, PhD, postdoctoral associate in the UB Department of Oral Biology.

The study examined two groups of mice fed vastly different diets over the course of 16 weeks: one group had a low-fat diet that derived 10 per cent of energy from fat, the other group a high-fat diet that drew 45 per cent of energy from fat.

The investigation found that the high-fat diet group experienced obesity, more inflammation and a greater increase of MDSCs in the bone marrow and spleen compared to the low-fat diet group. The high-fat diet group also developed a significantly larger number of osteoclasts and lost more alveolar bone (the bone that holds teeth in place).

Also, the expression of 27 genes tied to osteoclast formation were significantly elevated in the group fed a high-fat diet.

The findings may shed more light on the mechanisms behind other chronic inflammatory, bone-related diseases that develop concurrently with obesity, such as arthritis and osteoporosis, said Kirkwood.

Additional investigators include Lixia Zhang, PhD, a research scientist in the UB Department of Oral Biology; Jiho Sohn, a doctoral candidate in the Jacobs School of Medicine and Biomedical Sciences at UB; Victoria Maglaras, a student in the UB School of Dental Medicine; and Ramkumar Thiyagarajan, a research scientist in the Jacobs School. (ANI)

Have something to say? Post your comment
Must Read
Government College of Yoga Education & Health, Chandigarh in collaboration with MDNIY, New Delhi organize YOGOTSAV-2022
Government College of Yoga Education & Health, Chandigarh in collaboration with MDNIY, New Delhi organize YOGOTSAV-2022
Two associates of gangster-turned-terrorist Arsh Dalla held with MP-5 gun, 44 live rounds
Two associates of gangster-turned-terrorist Arsh Dalla held with MP-5 gun, 44 live rounds
Baisakhi Mela to promote Kanjli wetland as tourist destination- ADC (Urban Development)
Baisakhi Mela to promote Kanjli wetland as tourist destination- ADC (Urban Development)
Azad Hind Fauj freedom fighter passes away in Rahon
Azad Hind Fauj freedom fighter passes away in Rahon
Jahangirpuri violence case: FSL team conducts an investigation to collect evidence
Jahangirpuri violence case: FSL team conducts an investigation to collect evidence
Lifting touches 121 % and payment to 118 % in Kapurthala
Lifting touches 121 % and payment to 118 % in Kapurthala
One killed, four injured after iron mast falls on stage at Union Minister's event in Agra
One killed, four injured after iron mast falls on stage at Union Minister's event in Agra
Punjab govt transfers 32 IAS officers, find the complete list here
Punjab govt transfers 32 IAS officers, find the complete list here
“Congress is like a dead horse, there is no point flocking a dead horse”: Raghav Chadha attacks over Prashant Kishor's meeting with Congress
“Congress is like a dead horse, there is no point flocking a dead horse”: Raghav Chadha attacks over Prashant Kishor's meeting with Congress
Jalandhar Rural Police arrest a drug smugglers from Maqsudan, seize over 1 kg of cannabis
Jalandhar Rural Police arrest a drug smugglers from Maqsudan, seize over 1 kg of cannabis
Govt. provide reliable and affordable electricity, not free, free food will go bankrupt: Laxmi Kant  Chawla
Govt. provide reliable and affordable electricity, not free, free food will go bankrupt: Laxmi Kant Chawla
BJP leader Tajinder Pal Bagga files a complaint against Punjab CM Bhagwant Mann for entering Gurudwara Damdama Sahib in a drunk condition
BJP leader Tajinder Pal Bagga files a complaint against Punjab CM Bhagwant Mann for entering Gurudwara Damdama Sahib in a drunk condition